| 丹皮酚抗肿瘤作用及其机制研究 |
| |
| 引用本文： | 陈岳涛 曹蔚 王四旺 叶青雅. 丹皮酚抗肿瘤作用及其机制研究[J]. 现代生物医学进展, 2012, 12(21): 4163-4165 |
| |
| 作者姓名： | 陈岳涛 曹蔚 王四旺 叶青雅 |
| |
| 作者单位： | 1. 第四军医大学药学系天然药物学教研室 陕西西安710032
2. 解放军第九八医院药械科 浙江湖州313005 |
| |
| 基金项目： | 陕西省"13115"科技创新工程资助项目(2010ZDGC-19) |
| |
| 摘 要： | 丹皮酚主要通过杀伤肿瘤细胞、诱导凋亡,影响肿瘤血管生成,促进IL-2及TNF-α生成,下调COX-2表达发挥抗肿瘤作用;但我们研究证实丹皮酚对体外神经胶质瘤U251细胞及肝癌HepG2细胞无明显抑制作用。丹皮酚作为抗肿瘤有效中药分子开发新药尚需深入的体内外实验研究与探讨。
|
| 关 键 词： | 丹皮酚 抗肿瘤 作用机制 凋亡 |
The Progress in the Antitumor Effect and Mechanism of Paeonol |
| |
| CHEN Yue-tao,CAO Wei,WANG Si-wang,YE Qing-ya. The Progress in the Antitumor Effect and Mechanism of Paeonol[J]. Progress in Modern Biomedicine, 2012, 12(21): 4163-4165 |
| |
| Authors: | CHEN Yue-tao CAO Wei WANG Si-wang YE Qing-ya |
| |
| Affiliation: | 1 Institute of Material Medical,School of Pharmacy,Fourth Military Medical University,Xi’an,Shaanxi 710032; 2 Material Medical 98th Hospital,Huzhou,Zhejiang 313005) |
| |
| Abstract: | To summarize the progress in the antitumor effect and mechanism of Paeonol.Sum up the progress of studies on anti-tumor effect of Paeonol and its molecular mechanisms after a wide range of data collection.Paeonol can exert its anti-tumor effect by killing tumor cells,inducing apoptosis of tumour cell,inhibiting tumor angiogenesis,stimulating secretion of IL-2 and TNF-α and down-regulating expression of COX-2.Our research suggests that Paeonol has no significant effect on inhibiting proliferation of U251 cells and HepG2 cells.It needs deep discussion and study to develop Paeonol into an new anti-tumor drug as an effective Molecule of Chinese hebral drug. |
| |
| Keywords: | Paeonol Antitumor Mechanism Apoptosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 |
|
点击此处可从《现代生物医学进展》下载全文 |
