| 缝隙连接蛋白43 研究进展 |
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| 引用本文： | 李艳燕张博韩峰刘中洋金发光. 缝隙连接蛋白43 研究进展[J]. 现代生物医学进展, 2012, 12(19): 3731-3733 |
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| 作者姓名： | 李艳燕张博韩峰刘中洋金发光 |
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| 作者单位： | 第四军医大学唐都医院呼吸内科 陕西西安710038 |
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| 基金项目： | 陕西省公关项目(2008K14-08);军队十一五公关项目(08-G102) |
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| 摘 要： | 缝隙连接蛋白(Connexin,Cx)组成缝隙连接通道发挥其通讯功能,其本身也对细胞的生长、分化、凋亡、肿瘤具有调节作用。缝隙连接蛋白43(Cx43)在肺泡上皮和肺血管内皮高表达,在多种肺损伤的病理过程中起重要作用,因此成为研究热点。Cx43的表达和功能受多种因素的调节,丝裂原激活的蛋白激酶(MAPKs)是主要的调节途径。本文就Cx43在肺的病理生理过程中的作用及MAPK对其调节作用进行综述。
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| 关 键 词： | 缝隙连接蛋白43 肺损伤 |
Progress on Connexin43 |
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| LI Yan-yan,ZHANG Bo,HAN Feng,LIU Zhong-yang,JIN Fa-guang. Progress on Connexin43[J]. Progress in Modern Biomedicine, 2012, 12(19): 3731-3733 |
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| Authors: | LI Yan-yan ZHANG Bo HAN Feng LIU Zhong-yang JIN Fa-guang |
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| Affiliation: | (Department of Internal Respiratory,Tangdu Hospital of Fourth Military Medical University,Xi’an,Shaanxi,710038,China) |
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| Abstract: | Connexin43(Cx43) is the main component of gap junctions in alveolar epithelium and capillary endothelium,which is essential for intercellular information communication function.Cx43 is closely related to cell development,apoptosis.Cx43 is ubiquitous in both alveolar epithelial and endothelial cells,which is known as gap junction un-communication function.The expression of Cx43 in the lung can be altered in lung injuries such as radiation-induced pulmonary fibrosis,lipopolysaccharide or bleomycin-induced lung injury,and even in lung canner.Cx43 was regulated by Mitogen-activated protein kinase(MAPK) in pathological lungs.Therefore,Cx43 is thought to be a new therapeutic target to pulmonary disease. |
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| Keywords: | Connexins Lung injury |
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