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| 颊粘膜癌与舌癌差异基因表达的对比分析 | |
| 引用本文： | 陈双,甘冠华,楚凤婷,冯齐平.颊粘膜癌与舌癌差异基因表达的对比分析[J].现代生物医学进展,2012,12(16):3144-3146. |
| 作者姓名： | 陈双 甘冠华 楚凤婷 冯齐平 |
| 作者单位： | 1. 上海市田林街道社区卫生服务中心口腔科 上海200233 2. 浙江省嘉善县魏塘甘冠华口腔诊所 浙江嘉善314100 3. 上海市第九人民医院口腔正畸科 上海200011 |
| 基金项目： | 2010年上海基础研究计划(10ZR1432199) |
| 摘 要： | 目的:研究颊粘膜癌(Buccal Mucosa Cancer,BMC)与舌癌(Tongue Cancer,TC)的基因差异表达,探讨BMC与TC发生发展的基因学基础。方法:应用cDNA芯片技术对5例BMC和5例TC组织mRNA检测,通过芯片杂交、生物信息学处理,找出两者间差异表达基因。结果:BioStarH-40芯片发现差异表达基因503条,差异表达基因占12.9%,其中表达增强274条(显著增强69条),表达降低229条(显著降低54条)。结论:MBC与TC基因表达比较,差异有统计学意义,这些差异可能在两类肿瘤不同的生物学行为中起重要作用。 |
| 关 键 词： | 颊粘膜癌 舌癌 基因表达 |
Differences of Gene Expression Profile between Buccal Mucosa Cancer and Tongue Cancer |
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| CHEN Shuang,GAN Guan-hu,CHU Feng-ting,FENG Qi-ping.Differences of Gene Expression Profile between Buccal Mucosa Cancer and Tongue Cancer[J].Progress in Modern Biomedicine,2012,12(16):3144-3146. | |
| Authors: | CHEN Shuang GAN Guan-hu CHU Feng-ting FENG Qi-ping |
| Institution: | 1 Dept.of Oral Health,Community medical service centre of Tianlin Rd.District 200233,Shanghai,China; 2 Guanhua Dental Clinic,314112,Jiashan,Zhejiang China; 3 Dept.of Orthodontics,Shanghai Ninth People’s Hospital,Jiaotong University,200011,Shanghai,China) |
| Abstract: | Objective: To determine the difference in the gene expression between human buccal mucosa cancer(BMC) and tongue cancer(TC).Methods: cDNA chip was used to detect the mRNA of cancer tissue from 5 BMCs and 5 TCs.After profile bloted and handled by bioinformation,the gene expression of these two kinds of lesions was examined.Results: Using the BioStarH-40 profile,503 different expression of genes were found.The rate of different genes was 12.9%,of which the exprssion of 274 genes increased(69 genes significantly increased) and 229 genes decreased(54 genes significantly decreased) in BMC tissue than that in TC.Conclusions: The gene expression of BMC and TC was different,which may contribute to the different biological behavior of these two kinds of lesions. |
| Keywords: | Buccal mucosa cancer Tongue cancer Gene expression |
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