Th17/Treg 细胞在银屑病的发病机制研究进展

Th17细胞和Treg细胞是CD4+T细胞在不同细胞因子环境中分化出的新亚群,发挥不同的生物学效应,使机体的免疫系统处于平衡状态.Th17/Treg细胞失衡可引起一系列自身免疫性疾病.银屑病是与遗传、免疫异常有关的皮肤炎症性疾病,其发病机制尚不清楚.越来越多的研究发现,Th17细胞增多和Treg细胞减少及其分泌的细胞因子在银屑病的发病中有着重要作用.本文围绕这一机制综述了近年来有关Th17细胞、Treg细胞在银屑病发病机制中作用的研究,帮助我们更深入地了解银屑病的发病机制并为今后临床诊断和治疗提供依据.

Advancements in Th17/Treg Cells in the Pathogenesis of Psoriasis

Th17 cells and regulatory T cells(Tregs) are novel subsets from CD4+ T cells in different cytokines environments,which respectively play crucial roles in immune system to maintain the balance.Imbalance of Th17/Treg will lead to a series of autoim-mune diseases.Psoriasis,etiology unknown,is generally believed to be a complex autoimmune inflammatory disease with a genetic basis.Accumulating evidence indicates that either increased Th17 cells or decreased Tregs have a pathogenic role in psoriasis.The cytokines produced by them participate in the onset of psoriasis.This review summarizes the progress so far towards understanding the role of Th17 cells and regulatory T cells(Tregs) in psoriasis,which will further our understanding of the pathogenesis of psoriasis and provide promis-ing directions of clinical diagnosis and treatment.