MYH9 基因多态性与肾脏疾病关系研究进展

非肌性肌球蛋白重链9基因,编码非肌性肌球蛋白重链ⅡA,既往研究其与May-Hegglin异常(May-Hegglin anomaly,MHA)、Fechtner综合征(Fechtner syndrome,FTNS)、Sebastian综合征(Sebastian syndrome,SBS)、Epstein综合征(Epstein syndrome,EPS)和Alport样综合征相关。2008年首次用混合连锁不平衡绘图(MALD)方法证实其与非糖尿病终末期肾病及局灶节段性肾小球硬化症相关,后陆续有该基因与高血压肾病、C1q肾病等的相关报道。本文综合国外该基因与肾脏病的相关研究,对其与肾脏病的关系研究进展做一概括,对今后的研究起一定的帮助作用。

Research Progress in Relationship between MYH9 Gene Polymorphism and the Kidney Disease

Myosin heavy chain 9,non-muscle(MYH9),coding of non-muscular myosin heavy chain Ⅱ A,is in past research related with May-Hegglin anomaly(MHA),Fechtner syndrome(FTNS),Sebastian syndrome(SBS),Epstein syndrome(EPS) and Alport syndrome.In 2008,for the first time it was proved associated with non-diabetic end-stage renal disease(ESRD) and focal segmental glomerular sclerosis(FSGS) by mixed linkage disequilibrium mapping(MALD).Later there were relevant reports on this gene and hypertension nephropathy,C1q nephropathy.This article reviewed the related foreign research about the gene and kidney disease,and summarized the relationship of MYH9 with kidney disease.