中分子尿毒症毒素及其清除技术的研究进展

尿毒症毒素是一大组体内代谢的产物,在肾功能衰竭患者体液中水平明显升高,并与尿毒症毒素代谢紊乱或临床表现密切相关。一般认为中分子尿毒症毒素的分子量在500D-5000D之间。此类物质蓄积可促进尿毒症性心血管病变的发生发展、抑制机体免疫功能、加重患者营养不良等。研究发现,通过高通量透析、血液透析滤过和血液灌流等方法增加中分子尿毒症毒素的清除,可以为患者带来更好的生活质量和长期生存获益。

Progress of Middle Molecular Weight Uremic Toxins and Removal Techniques

Uremic toxins are a large group of metabolites,which have significantly higher levels in body fluids of renal failure patients,and are related with toxins metabolic disorders and clinical manifestations closely.It is generally believed that the middle molec-ular weight uremic toxins are in the interval 500D-5000D.Accumulation of such substances can promote the occurrence of uremic car-diovascular disease development,suppress of immune function,contribute to malnutrition.Researchers found that high-flux dialysis,hemodiafiltration and hemoperfusion and other methods may increase the removal of middle molecular weight uremic toxins,and can bring a better quality of life of patients and long-term survival benefit.