血清IL-17 与妊娠期糖尿病发病及新生儿出生体重的相关性研究

目的:探讨母体与脐血清白介素-17(interleukin-17 IL-17)与妊娠期糖尿病发病(gestational diabetes mellitus GDM)及新生儿出生体重相关性。方法:收集我院足月GDM患者26例为病例组,孕24-28周经50g葡萄糖筛查试验无异常者26例为对照组,分娩前收集两组母血清及脐血清,检测母血清空腹血糖及空腹胰岛素,稳态模型评估胰岛素抵抗(homeostasis model assessment insulin resistance HOMA-IR)。检测两组母血清及脐血清IL-17水平,探讨与妊娠期糖尿病发病及新生儿出生体重相关性。结果:GDM组空腹胰岛素、HOMA-IR、母血清IL-17、脐血清IL-17与对照相比具有统计学差异(P<0.05)。相关研究发现,母血清IL-17水平与HOMA-IR存在明显正相关(r=0.718,P<0.001),脐血清IL-17与新生儿体重存在相关性(r=0.686 P<0.001),但脐血清IL-17水平与母血清IL-17水平无相关性(r=-0.339,P=0.0899)。结论:IL-17可能通过胰岛素抵抗参与了GDM的发生。

Level of Serum IL-17 in Gestational Diabetes and its Correlationwith Neonatal Birth Weight

Objective: To evaluate maternal and cord blood serum IL-17 in gestational diabetes mellitus(GDM) and its correlation with neonatal birth weight.Methods: To collect 26 term GDM in our hospital as case group,and 26 cases with no abnormal 50g glucose challenge test in 24-28 weeks as control group.Maternal serum before delivery and cord blood serum were collected.Fasting blood glu-cose testing and fasting insulin,homeostasis model assessment insulin resistance(HOMA-IR) were tested in maternal serum.IL-17 levels were detected in maternal serum and cord blood serum to explore the pathogenesis of gestational diabetes and its correlation with neona-tal birth weight.Results: Fasting insulin,HOMA-IR,IL-17 in maternal serum,IL-17 in cord blood serum had significant difference in GDM group compared with control(P<0.05).It was found that maternal serum IL-17 levels existed positively correlated with HOMA-IR(r = 0.718,P <0.001),IL-17 in cord blood serum was correlated with neonatal birth weight(r = 0.686 P <0.001),but IL-17 in cord blood serum had no correlation with maternal serum levels(r =-0.339,P = 0.0899).Conclusion: IL-17 may be involved in insulin resistance with the occurrence of GDM.