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Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands |
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| Authors: | Arnusch Christopher J André Sabine Valentini Paola Lensch Martin Russwurm Roland Siebert Hans-Christian Fischer Marcel J E Gabius Hans-Joachim Pieters Roland J |
| Affiliation: | Utrecht Institute for Pharmaceutical Sciences, Department of Medicinal Chemistry, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands. |
| Abstract: | A library of pentapeptides containing the sequence -Y-X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry. |
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