Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels |
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Authors: | Tomohiro Asai Mayumi Nagatsuka Koichi Kuromi Satoru Yamakawa Kohta Kurohane Koichi Ogino Michinori Tanaka Takao Taki Naoto Oku |
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Institution: | Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
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Abstract: | Novel peptides homing to angiogenic vessels were recently isolated from a phage-displayed random pentadecapeptide library. One of the isolated peptides, ASSSYPLIHWRPWAR, significantly suppressed the migration of VEGF-stimulated human umbilical vein endothelial cells. Dendoric ASSSYPLIHWRPWAR-peptide suppressed the formation of new blood vessels in dorsal air sac model mice. Furthermore, ASSSYPLIHWRPWAR-peptide and the fragment peptides containing WRP, which is revealed to be an epitope sequence, significantly suppressed the tumor growth, although 15-mer shuffled peptide derived from ASSSYPLIHWRPWAR and pentapeptides with alanine substitution of each residue of WRP did not. Taken together, ASSSYPLIHWRPWAR-peptide may cause tumor dormancy through inhibition of angiogenesis, and the WRP sequence may be the minimal and essential sequence for this activity. |
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Keywords: | Phage-displayed peptide library Angiogenesis Drug delivery system WRP Tumor dormancy |
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