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Effects of a carotene-deficient diet on measures of oxidative susceptibility and superoxide dismutase activity in adult women |
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| Authors: | Zisca R Dixon Betty J Burri Andrew Clifford Edwin N Frankel Barbara O Schneeman Elizabeth Parks Nancy L Keim Teresa Barbieri Mei-Miau Wu Alice KH Fong Mary J Kretsch Anne L Sowell John W Erdman Jr |
| Institution: | * Western Human Nutrition Research Center, USDA/ARS/PWA, Presidio of San Francisco, CA, USA ? Department of Nutrition, University of California, Davis, CA, USA ? Department of Food Science and Technology, University of California, Davis, CA, USA § Nutritional Biochemistry Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA ¶ Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA |
| Abstract: | The effect of consuming a low carotene diet (≈60 μg carotene/day) on oxidative susceptibility and superoxide dismutase (SOD) activity in women living in a metabolic research unit was evaluated. The diet had sufficient vitamins A, E, and C. The women ate the diet supplemented with 1500 μg/day β-carotene for 4 days (baseline), then the unsupplemented diet for 68 days (depletion), followed by the diet supplemented with > 15,000 μg/day carotene for 28 days (repletion). Production of hexanal, pentanal, and pentane by copper-oxidased plasma low density lipoproteins from carotene-depleted women was greater than their production of these compounds when repleted with carotene. Erythrocyte SOD activity was depressed in carotene-depleted women; it recovered with repletion. Thiobarbituric acid reactive substances in plasma of carotene-depleted women were elevated and diminished with repletion. Dietary carotene seems to be needed, not only as a precursor of vitamin A, but also to inhibit oxidative damage and decrease oxidation susceptibility. |
| Keywords: | Carotene Human Oxidative damage Superoxide dismutase Free radicals |
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