Characterization of a murine thymic CD4~ T cell subset-TCRαβ~ 3G11~- 6C10~- CD4~ CD8~- thymocytes |
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引用本文: | 葛青
,陈慰峰.Characterization of a murine thymic CD4~ T cell subset-TCRαβ~ 3G11~- 6C10~- CD4~ CD8~- thymocytes[J].中国科学:生命科学英文版,1999(4). |
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作者姓名: | 葛青 陈慰峰 |
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作者单位: | Department of Immunology,Beijing Medical University,Beijing 100083,China |
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基金项目: | Project supported by the National Natural Science Foundation of China (Grant No. 39730410). |
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摘 要: | The presence of a relatively mature CD4 ~ CD8~- (SP) T cell subset in mouse thymus has been demonstrated. Composing of 10% of total CD4SP thymocytes, this subset is defined by the absence of 3G11 and 6C10 expression with a phenotype of CD69~( /-), HSA~(med/lo) and heterogeneous for Qa-2 expression. The proliferation capability of TCRαβ~ 3G11~- 6C10~- CD4~ CD8~- thymocytes was high while using Con A stimulus. And Con A stimulation could result in secretion of IL-4, IL-10, IL-6 and a little amount of IFNγ. IL-2 was barely detectable. This is distinct from typical Th0 type cytokines. The cells of this subset were NK1.1 negative, but strongly expressed GATA-3 mRNA. The results suggest that the CD4~ subset of 3G11~- 6C10~- NK1.1~- phenotype possesses immunocompetent cells with functions characteristic of Th2-like cytokines, which may indicate the cells at transitional status from Th0 to Th2, with a propensity to Th2.
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关 键 词: | TCRαβ~( 3)Gll~-6C10~-CD4~ CD8~- thymocytes phenotype cytokine. |
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