Calibration of beam deflection produced by cellular forces in the 10−9–10−6 gram range |
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Authors: | E A Evans R Kwok T McCown |
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Institution: | (1) Department of Biomedical Engineering, Duke University, 27706 Durham, North Carolina |
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Abstract: | An experimental procedure and method of analysis are presented for calibration of a thin-beam force transducer. The beam transducer
can be produced and calibrated with a minimum coefficient of 10 ng (10−5 dyne) force per micron (10−4 cm) deflection, i.e.,k
B∼0.1 dyne/cm. Since beam deflections on the order of 0.1 μm can be detected, forces of a few nanograms can be resolved. Such
forces are common in mechanical experiments on microscopic bodies, e.g., biological cells, artificial membrane capsules, droplets,
etc. |
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Keywords: | Nanogram force measurement cell mechanics microvesicle mechanics |
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