Listeria as a vaccine vector |
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| Authors: | Bruhn Kevin W Craft Noah Miller Jeff F |
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| Affiliation: | Department of Medicine, Division of Dermatology, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA. kbruhn@ucla.edu |
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| Abstract: | The immunostimulatory characteristics and intracellular niche of Listeria monocytogenes make it uniquely suitable for use as a live bacterial vaccine vector. Preclinical results supporting this idea, and current strategies to induce beneficial cell-mediated immunity to both infectious diseases and cancer with this vector, are discussed in this review. |
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