Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions |
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Authors: | Widmer Isabelle Wernli Marion Bachmann Felix Gudat Fred Cathomas Gieri Erb Peter |
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Affiliation: | Institute for Medical Microbiology, University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland. |
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Abstract: | Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells of late-stage Kaposi's sarcoma lesions but not in primary effusion lymphoma cell lines. In contrast, strong expression of human Bcl-2 was found in stimulated primary effusion lymphoma cells, whereas in Kaposi's sarcoma lesions preferential mononuclear cells, and to a lesser extent spindle cells, stained positive. |
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