Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution |
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| Authors: | Anders L Kjeldbjerg Palle Villesen Lars Aagaard Finn Skou Pedersen |
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| Affiliation: | (1) Department of Molecular Biology, University of Aarhus, DK-8000 Aarhus C, Denmark;(2) Bioinformatics Research Center, University of Aarhus, DK-8000 Aarhus C, Denmark |
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| Abstract: | Background Most human endogenous retroviruses (HERVs) invaded our genome at least 25 million years ago. The majority of the viral genes are degenerated, since no selection preserves them within the genome. However, a few intact and very old HERV genes exist, and likely are beneficial for the host. We here address evolutionary aspects of two HERV-V envelope genes, ENVV1 and ENVV2, located in tandem and containing a long open reading frame. |
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