Tay-Sachs disease: high gene frequency in a non-Jewish population. |
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| Authors: | T E Kelly G A Chase M M Kaback K Kumor V A McKusick |
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| Affiliation: | Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. |
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| Abstract: | A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews. |
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