CRM1-dependent trafficking of retroviral Gag proteins revisited |
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| Authors: | Baluyot Mariju F Grosse Sarah A Lyddon Terri D Janaka Sanath K Johnson Marc C |
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| Institution: | New York Medical College, Valhalla, New York, USA. |
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| Abstract: | We analyzed the nuclear trafficking ability of Gag proteins from six retroviral genera. Contrary to a previous report, human immunodeficiency virus type 1 (HIV-1) Gag showed no propensity to cycle through the nucleus. The only Gag protein that displayed CRM1-dependent nuclear cycling was that of Rous sarcoma virus (RSV). Surprisingly, this cycling could be eliminated without compromising infectivity by replacing the RSV Gag N-terminal matrix (MA) domain with HIV MA. |
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