经验改变大鼠听皮层神经元的特征频率

应用常规电生理学技术，以神经元的特征频率和频率调谐曲线为指标，研究大鼠听皮层神经元特征频率的可塑性. 结果表明，在给予的条件刺激频率和神经元特征频率相差1.0 kHz范围内，条件刺激可诱导50%以上神经元特征频率发生完全偏移，并可分为向频率调谐曲线的低频端偏移、高频端偏移，或两侧均可偏移三种类型. 其中，神经元的特征频率高、Q₁₀-dB值大和频率调谐曲线对称指数大于零的神经元，其特征频率偏向频率调谐曲线高频端的概率更高. 结果提示，经验可改变大鼠听皮层神经元的特征频率，为深入研究中枢神经元功能活动可塑性的机制提供了重要实验资料.

Experience Alters The Characteristic Frequency of Experience Alters The Characteristic Frequency of Primary Auditory Cortical Neuron in The Rat

Using conventional electrophysiological technique, the plasticity of characteristic frequency (CF) of neurons in rat auditory cortex (AC) was investigated by determining CF and frequency tuning curve (FTC) shifts of neurons. In the AC, when the frequency difference between conditioned stimulus frequency(CSF) and the CF of neuron was in 1.0 kHz with conditioned stimulation for 30 min, 61 of 120 neurons (50.8%) completely shifted their CF to the CSF. According to the CF shift direction, complete CF shifts were classified into three patterns: CF shift toward lower frequency side(LFS) of neuron's FTC, CF shift to higher frequency side(HFS) and CF shift to both LFS and HFS. Among them, some neurons with higher CF, bigger Q₁₀-dB value and symmetry index > 0 of FTC, the probability of CF shift toward HFS of FTC is higher than other neurons. The results suggest that the experience can alter CF in rat auditory cortical neurons. These findings also provide evidence for further study of plasticity mechanisms in sensory function of the brain.