Effects of glucose and acetylcholine on islet tissue NADH and insulin release. |
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| Authors: | M D Trus C S Hintz J B Weinstein A D Williams A S Pagliara F M Matschinsky |
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| Institution: | 1. Established Investigator of the American Diabetes Association, USA |
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| Abstract: | The relationship between islet tissue NADH and insulin release resulting from glucose or acetylcholine was investigated with the isolated perfused rat pancreas. Switching the perfusate from 4 to 16 mM glucose or adding 1 μM acetylcholine to 4.4 mM basal glucose elicited biphasic insulin release and rapidly elevated the NADH content of islet tissue, suggesting that intermediary metabolism was stimulated. The biochemical basis for this NADH increase and its significance in islet physiology are discussed. |
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