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Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
Authors:Rachaneeporn Tiyawisutsri  Matthew TG Holden  Sarinna Tumapa  Sirirat Rengpipat  Simon R Clarke  Simon J Foster  William C Nierman  Nicholas PJ Day  Sharon J Peacock
Affiliation:(1) Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;(2) Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand;(3) The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK;(4) Faculty of Sciences, Chulalongkorn University, Bangkok, Thailand;(5) Department of Molecular Biology & Biotechnology University of Sheffield, Western Bank, S10 2TN Sheffield, UK;(6) The Institute for Genomic Research, 20850 Rockville, Maryland, USA;(7) Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, 20037 Washington, DC, USA;(8) Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, OX3 9LJ Oxford, UK
Abstract:

Background  

The bacterial biothreat agents Burkholderia mallei and Burkholderia pseudomallei are the cause of glanders and melioidosis, respectively. Genomic and epidemiological studies have shown that B. mallei is a recently emerged, host restricted clone of B. pseudomallei.
Keywords:
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