(1) Department of Cell Biology and Physiology, Institute for Biomedical Research, National Autonomous University of Mexico (UNAM), Apartado Postal 70228, 04510 Mexico City, Mexico
Abstract:
Background
17alpha-Estradiol has been considered as the hormonally inactive isomer of 17beta-estradiol. Recently, nongenomic (smooth muscle relaxation) and genomic (light estrogenic activity) effects of 17alpha-estradiol have been reported, but no reports have yet determined its possible antiestrogenic activity. Therefore, this study investigated: the nongenomic action of 17alpha-estradiol on uterine contractile activity and its potential agonist-antagonist activity on uterine growth.
