The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats |
| |
| Authors: | A K Baltaci H Gokbudak R Mogulkoc M C Avunduk |
| |
| Institution: | 1. Department of Physiology, Faculty of Medicine, Sel?uk University, Konya, Turkey;2. Meram Faculty of Medicine, Department of Pathology, Necmettin Erbakan University, Konya, Turkey |
| |
| Abstract: | ABSTRACTWe investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups. |
| |
| Keywords: | Histopathology lipid oxidation rat renal ischemia reperfusion resveratrol |
|
|
