Trace element correlations in the blood of indian women with breast cancer |
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Authors: | Vivek Singh A N Garg |
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Institution: | (1) Department of Chemistry, Nagpur University, 440010 Nagpur, India;(2) Department of Chemistry, University of Roorkee, Roorkee, 247667 Uttar Pradesh, India |
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Abstract: | Fourteen minor (Na, K, P, Fe) and trace (Br, Co, Cr, Cs, Hg, Rb, Sb, Se, Sr, Zn) elements have been determined in pre and
postoperative blood samples of 10 breast-cancer-affected. Indian women and compared with controls. The study showed elevation
of Cr, Hg, Fe, Rb, Sb, and Zn and lowering of Se, K, P, and Sr contents in the blood of cancer patients. Most elemental contents
in pre and postoperative stages remain unaltered except Br, Co, and Sb. Statistical significance of Fe, Se, Zn, and Hg levels
has been tested by box plots. Lowering of Se in blood (-54.4%) is correlated with its enhancement in cancerous breast tissue
(94.7%) of various clinical stages. Se/Zn and Se/Fe ratios are lowered in the blood of cancer patients, whereas Na/K ratio
is only marginally enhanced. An attempt has been made to correlate Se levels with the dietary intake and breast cancer risk
vis-a-vis American and Japanese women. |
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Keywords: | Breast cancer trace elements blood neutron activation analysis selenium zinc dietary intake |
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