Effects of the nonsteroidal anti-inflammatory drug piroxicam on energy metabolism in the perfused rat liver |
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| Affiliation: | 1. Center for Cell Reprograming, Department of Pathology, Georgetown University Medical Center, Washington DC, USA;2. Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, University of California Davis, Washington DC, USA;3. Department of Urology, Renmin Hospital, Wuhan University, Washington DC, USA;4. Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA;5. Department of Urology, MedStar Washington Hospital Center, Washington DC, USA;6. Department of Urology, MedStar Georgetown Hospital, Washington DC, USA;7. Department of Oncology, MedStar Georgetown Hospital, Washington DC, USA;8. VA Northern California Health Care System, Mather, CA, USA;1. Pharmacokinetics Modeling Laboratory, PK/PD, Pharmaceutical Sciences Post-Graduation Program, Pharmacy College, Federal University of Rio Grande do Sul, Brazil;2. Agriculture and Livestock Laboratory, LANAGRO, Rio Grande do Sul, Brazil;1. Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA;2. Department of Neurology, Movement Disorders Clinic, Albany Medical Center, 47 New Scotland Ave, Albany, NY 12208, USA;3. Department of Neurosurgery, Albany Medical Center, 47 New Scotland Ave, Albany, NY 12208, USA |
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| Abstract: | - 1.1. The actions of piroxicam, a nonsteroidal and noncarboxylic anti-inflammatory drug, on the metabolism of the isolated perfused rat liver were investigated. The main purpose was to verify if piroxicam is also active on glycogenolysis and energy metabolism, as demonstrated for several carboxylic nonsteroidal anti-inflammatories.
- 2.2. Piroxicam increased oxygen consumption in livers from both fed and fasted rats.
- 3.3. Piroxicam increased glucose release and glycolysis from endogenous glycogen (glycogenolysis).
- 4.4. Gluconeogenesis from lactate plus pyruvate was inhibited.
- 5.5. The action of piroxicam on oxygen consumption was blocked by antimycin A, but not by atractyloside.
- 6.6. The action of piroxicam in the perfused rat liver metabolism seems to be a consequence of its action on mitochondria.
- 7.7. It can be concluded that inhibition of energy metabolism and stimulation of glycogenolysis are not specific properties of carboxylic nonsteroidal anti-inflammatory drugs.
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