Monitoring maturation of neural stem cell grafts within a host microenvironment |
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Authors: | Olga Kopach |
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Affiliation: | Olga Kopach, Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, University College London, London WC1 N3BG, United Kingdom |
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Abstract: | Neural stem cells (NSC) act as a versatile tool for neuronal cell replacement strategies to treat neurodegenerative disorders in which functional neurorestorative mechanisms are limited. While the beneficial effects of such cell-based therapy have already been documented in terms of neurodegeneration of various origins, a neurophysiological basis for improvement in the recovery of neurological function is still not completely understood. This overview briefly describes the cumulative evidence from electrophysiological studies of NSC-derived neurons, aimed at establishing the maturation of differentiated neurons within a host microenvironment, and their integration into the host circuits, with a particular focus on the neurogenesis of NSC grafts within the post-ischemic milieu. Overwhelming evidence demonstrates that the host microenvironment largely regulates the lineage of NSC grafts. This regulatory role, as yet underestimated, raises possibilities for the favoured maturation of a subset of neural phenotypes in order to gain timely remodelling of the impaired brain tissue and amplify the therapeutic effects of NSC-based therapy for recovery of neurological function. |
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Keywords: | Neural stem cells Embryonic progenitors Neurogenesis Maturation of neurophysiological properties Integration into network Neural stem cell therapy Neurodegeneration Ischemic injury |
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