Long non-coding RNA: The functional regulator of mesenchymal stem cells |
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Authors: | Zhong-Yu Xie Peng Wang Yan-Feng Wu Hui-Yong Shen |
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Affiliation: | Zhong-Yu Xie, Peng Wang, Hui-Yong Shen, Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, Guangdong Province, ChinaYan-Feng Wu, Center for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong Province, China |
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Abstract: | Mesenchymal stem cells (MSCs) are a subset of multipotent stroma cells residing in various tissues of the body. Apart from supporting the hematopoietic stem cell niche, MSCs possess strong immunoregulatory ability and multiple differentiation potentials. These powerful capacities allow the extensive application of MSCs in clinical practice as an effective treatment for diseases. Therefore, illuminating the functional mechanism of MSCs will help to improve their curative effect and promote their clinical use. Long noncoding RNA (LncRNA) is a novel class of noncoding RNA longer than 200 nt. Recently, multiple studies have demonstrated that LncRNA is widely involved in growth and development through controlling the fate of cells, including MSCs. In this review, we highlight the role of LncRNA in regulating the functions of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment. |
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Keywords: | Mesenchymal stem cells Long non-coding RNA Regulator Multipotent stroma cells |
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| 点击此处可从《World journal of stem cells》浏览原始摘要信息 |
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