In vivo evidence that the increase in matrix metalloproteinase activity occurs early after cerebral ischemia |
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Authors: | Martín Abraham Garofalakis Anikitos Tavitian Bertrand |
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Affiliation: | INSERM U1023, Université Paris Sud, France. amartin@cicbiomagune.es |
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Abstract: | There is controversy over whether matrix metalloproteinases (MMPs) are activated during the early therapeutic window following ischemic stroke. Ex vivo, an increase was reported as early as 4 hours, whereas in vivo, no increase was found until 24 hours postischemia. We used fluorescence diffuse optical tomography to image MMP activity following experimental cerebral ischemia; increased MMP activity was observed in the ischemic area as early as 3 to 6 hours after ischemic onset and correlated with the volume of ischemic cerebral tissue. Therefore, MMP activation is an immediate early response to cerebral ischemia concurrent with the therapeutic window. |
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