Intracellular membrane transport systems in Trypanosoma brucei |
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Authors: | Field Mark C Carrington Mark |
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Affiliation: | Department of Biological Sciences, Imperial College, London, UK. mfield@mac.com |
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Abstract: | Trypanosomes belong to the order kinetoplastida, an early diverging group of organisms in the eukaryotic lineage. The principal reasons for interest in these organisms are twofold; they provide a superb distant triangulation point from which to assess global features of eukaryotic biology and, more importantly, they are representative of a number of pathogenic parasitic protozoa with a huge public health impact --Trypanosoma brucei, T. cruzi and Leishmania spp. Recent advances in the study of intracellular transport in T. brucei have been considerable, and a fuller picture of the complexity, function and role that the endomembrane system plays in trypanosomes is finally emerging. |
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Keywords: | clathrin Rab small G protein trypanosoma vesicle trafficking |
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