DNA repair: the importance of phosphorylating histone H2AX |
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| Authors: | Lowndes Noel F Toh Geraldine W-L |
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| Affiliation: | Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland. |
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| Abstract: | How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together. |
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