Metachlopromide-induced hyperprolactinemia fails to affect ovarian cyclicity in the common marmosets (Callithrix jacchus) |
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Authors: | S D Kholkute Rohini P Patil Meena P Desai C P Puri |
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Institution: | (1) Institute for Research in Reproduction (ICMR), 400012 Parel, Bombay, India |
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Abstract: | Intramuscular administration of metachlopromide (2.5, 5, and 10 mg) induced a dose-dependent increase in plasma prolactin
levels. The magnitude and duration of metachlopromide-induced hyperprolactinemia were also dose related. However, metachlopromide
treatment (5 mg/day) for 60 days failed to affect ovarian function in the common marmoset as evidenced by ovulatory plasma
estradiol and progesterone profiles. During the pretreatment cycle, there was no consistent pattern in plasma prolactin levels
depending on the stage of cycle. During lactation, higher levels of plasma prolactin were observed. |
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Keywords: | Marmoset Hyperprolactinemia Metachlopromide Ovarian function Lactation |
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