Protocol of a prospective study on the diagnostic value of transcranial duplex scanning of the substantia nigra in patients with parkinsonian symptoms |
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| Authors: | Annemarie MM Vlaar Angela EP Bouwmans Marinus JPG van Kroonenburgh Werner H Mess Selma C Tromp Piet GWM Wuisman Alfons GH Kessels Ania Winogrodzka Wim EJ Weber |
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| Affiliation: | (1) Department of Neurology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;(2) Department of Nuclear Medicine, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;(3) Department of Clinical Neurophysiology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;(4) Department of Clinical Neurophysiology, Maasland Hospital, P.O. Box 5500, 6130 MB Sittard, The Netherlands;(5) Department of Clinical Epidemiology and Technology Assessment, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands |
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| Abstract: | Background Parkinson's disease (PD) is the second most common neurodegenerative disorder. As there is no definitive diagnostic test, its diagnosis is based on clinical criteria. Recently transcranial duplex scanning (TCD) of the substantia nigra in the brainstem has been proposed as an instrument to diagnose PD. We and others have found that TCD scanning of substantia nigra duplex is a relatively accurate diagnostic instrument in patients with parkinsonian symptoms. However, all studies on TCD so far have involved well-defined, later-stage PD patients, which will obviously lead to an overestimate of the diagnostic accuracy of TCD. |
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