A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase. |
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| Authors: | T Kunieda E Kobayashi M Tachibana H Ikadai |
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| Institution: | Imamichi Institute for Animal Reproduction, Ibaraki, Japan. |
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| Abstract: | A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/Iar x IS/Iar)F1 x WKS/Iar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes. |
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