Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs |
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| Authors: | Toba Tetsuya Murata Kenji Nakanishi Kyoko Takahashi Bitoku Takemoto Naohiro Akabane Minako Nakatsuka Takashi Imajo Seiichi Yamamura Takashi Miyake Sachiko Annoura Hirokazu |
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| Affiliation: | Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd, Japan. |
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| Abstract: | Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of alpha-GalCer (1)/hCD1d complex is also described. |
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