Tetradifon: an oligomycin-like inhibitor of energy-linked activities of rat liver mitochondria |
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Authors: | E Bustamante P L Pedersen |
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Affiliation: | Department of Physiological Chemistry The Johns Hopkins University School of Medicine Baltimore, Maryland 21205 USA |
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Abstract: | Tetradifon (p-chlorophenyl-2,4,5-trichlorophenyl sulfone) at concentrations between 4.5 and 27.0 nmoles/mg mitochondrial protein provides half-maximal inhibition of the following energy-linked activities of rat liver mitochondria: ADP-stimulated respiration, DNP-stimulated ATPase activity, Mg++-stimulated ATPase activity, and Pi-ATP exchange activity. Tetradifon has no effect on the activity of soluble ATPase purified from rat liver mitochondria. Respiration inhibited by tetradifon is restored upon addition of 2,4-dinitrophenol. It is concluded that tetradifon acts at or near the oligomycin sensitivity conferring complex located in the mitochondrial inner membrane. |
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