谷氨酸受体与药物成瘾的相关研究

谷氨酸是中枢神经系统中最重要的兴奋性神经递质,其受体分为离子型和代谢型,受体激活后通过对Na+、K+、Ca2+等阳离子调节或通过与G蛋白偶联,从而激活一系列信号转导途径,参与记忆形成。药物成瘾是一种慢性、复发性脑疾病,以强迫性药物寻求以及丧失对药物使用控制能力为主要特征。研究表明谷氨酸受体与药物成瘾的发生发展有关,就谷氨酸受体在药物成瘾中作用的研究做一综述。

The study on relationship between glutamate receptors and drug addiction

Glutamate is the most important excitatory neurotransmitter in central nervous system. Glutamate receptors include ionotropic and metabotropic glutamate receptors. After receptors are activated, they regulate ion channels for Na＋, K＋, Ca2＋or couple with G protein and activate a series of series of complex signal transductions as well as are involved in memory formation. Drug addiction is a chronic, relapsing brain disease characterized by compulsive drug seeking and loss of ability to control drug use. It has been reported that glutamate receptors are closely related to drug addiction. This paper will review studies on the roles of glutamate receptors in drug addiction.