Complete nucleotide sequence of the N-terminal domains of the murine alpha-1 type-III collagen chain |
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Authors: | L Wood N Theriault G Vogeli |
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Institution: | Molecular Biology Research, Upjohn Company, Kalamazoo, MI 49001. |
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Abstract: | We present the complete nucleotide (nt) sequence and derived amino acid (aa) sequence of the N-terminal portion of the murine alpha-1 type-III collagen chain. The detailed structure of this region is important for the understanding of type-III collagen biosynthesis in normal tissue and during fibrosis. The cDNA clones, pCIII-1-C119, pCIII-1-C534 and pCIII-1-C572, covering a total of 1485 nt, code for 19 nt of the 5' untranslated region, the 24 aa of the signal peptide, the 130 aa of the N-terminal propeptide, the 9 aa of the telopeptide and 334 aa of the helical domain. |
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