Functional implications of ribosomal RNA methylation in response to environmental stress |
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Authors: | Kevin C. Baldridge |
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Affiliation: | McKetta Department of Chemical Engineering, The University of Texas at Austin Austin, TXUSA |
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Abstract: | AbstractThe study of post-transcriptional RNA modifications has long been focused on the roles these chemical modifications play in maintaining ribosomal function. The field of ribosomal RNA modification has reached a milestone in recent years with the confirmation of the final unknown ribosomal RNA methyltransferase in Escherichia coli in 2012. Furthermore, the last 10 years have brought numerous discoveries in non-coding RNAs and the roles that post-transcriptional modification play in their functions. These observations indicate the need for a revitalization of this field of research to understand the role modifications play in maintaining cellular health in a dynamic environment. With the advent of high-throughput sequencing technologies, the time is ripe for leaps and bounds forward. This review discusses ribosomal RNA methyltransferases and their role in responding to external stress in Escherichia coli, with a specific focus on knockout studies and on analysis of transcriptome data with respect to rRNA methyltransferases. |
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Keywords: | Adaptation cold shock extremophile heat shock methyltransferase oxidative stress prokaryote transcriptome |
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