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Synthesis of peptide nucleic acid-peptide chimeras carrying the c-myc tag-sequence |
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| Authors: | Gottschling Dirk Seliger Hartmut Tarrasón Gema Piulats Jaume Wiersma Marten Eritja Ramon |
| Institution: | 1.European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany ;2.Sektion Polymere, Universität Ulm, Albert-Einstein-Allee 11, D-89081, Ulm, Germany ;3.Laboratori deBioInvestigació, C/Casp 108, Merck Farma-Química, E-08010, Barcelona, Spain ;4.European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany ; |
| Abstract: | Summary The preparation of peptide nucleic acids (PNA) carrying a c-myc tag-peptide sequence is described. These PNA-peptide chimeras have higher affinity to complementary DNA than unmodified oligonucleotides. Moreover, they can be used as nonradioactive probes with sensitivity similar to other nonradioactive methods. |
| Keywords: | nonradioactive labeling peptide nucleic acids PNA PNA-peptide chimera tag-peptide |
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