Nicotinamide stimulates repair of DNA damage in human lymphocytes |
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Authors: | N A Berger G W Sikorski |
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Affiliation: | The Hematology/Oncology Division of The Department of Medicine, Washington University School of Medicine at The Jewish Hospital of St. Louis 216 South Kingshighway St. Louis, MO 63110 USA |
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Abstract: | Nicotinamide stimulates the amount of DNA repair synthesis that occurs when freshly isolated, normal human lymphocytes are treated with UV irradiation, N-methyl-N′-nitro-N-nitroso guanidine, or dimethyl sulfate. Stimulation of DNA repair synthesis is concentration dependent and reaches a maximum between 2 to 5 mM nicotinamide. In contrast, DNA synthesis in cells that have not been subjected to DNA damage is not affected by nicotinamide at concentrations below 2 mM and is inhibited by concentrations between 2 to 5 mM. In the same concentration range, nicotinic acid has no effect on the rate of DNA synthesis in the presence or absence of DNA damage. |
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