Novel Aspects of Prions,Their Receptor Molecules,and Innovative Approaches for TSE Therapy |
| |
Authors: | Karen Vana Chantal Zuber Daphne Nikles Stefan Weiss |
| |
Affiliation: | 1.Laboratorium für Molekulare Biologie,Genzentrum, Institut für Biochemie der Ludwig-Maximilians-Universit?t München,München,Germany |
| |
Abstract: | 1. Prion diseases are a group of rare, fatal neurodegenerative diseases, also known as transmissible spongiform encephalopathies (TSEs), that affect both animals and humans and include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep, chronic wasting disease (CWD) in deer and elk, and Creutzfeldt–Jakob disease (CJD) in humans. TSEs are usually rapidly progressive and clinical symptoms comprise dementia and loss of movement coordination due to the accumulation of an abnormal isoform (PrPSc) of the host-encoded prion protein (PrPc). 2. This article reviews the current knowledge on PrPc and PrPSc, prion replication mechanisms, interaction partners of prions, and their cell surface receptors. Several strategies, summarized in this article, have been investigated for an effective antiprion treatment including development of a vaccination therapy and screening for potent chemical compounds. Currently, no effective treatment for prion diseases is available. 3. The identification of the 37 kDa/67 kDa laminin receptor (LRP/LR) and heparan sulfate as cell surface receptors for prions, however, opens new avenues for the development of alternative TSE therapies. |
| |
Keywords: | bovine spongiform encephalopathy Creutzfeldt– Jakob disease heparan sulfate 37 kDa/67 kDa laminin receptor LRP/LR prion PrP therapy transmissible spongiform encephalopathy |
本文献已被 PubMed SpringerLink 等数据库收录! |
|