Effects of follicle-stimulating hormone and vitamin A upon purinergic secretion by rat Sertoli cells |
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Authors: | Daniel Pens Gelain Emerson André Casali Ramatis Birnfeld de Oliveira Luiz Fernando de Souza Fabiano Barreto Felipe Dal-Pizzol José Cláudio Fonseca Moreira |
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Institution: | (1) Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;(2) Departamento de Bioquímica, UFRGS, Laboratório 25. Rua Ramiro Barcelos 2600 anexo, CEP 90035-003 Porto Alegre, RS, Brazil |
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Abstract: | Follicle-stimulating hormone (FSH) and vitamin A (retinol) are two of the main regulators of the male reproductive system.
Recently, it has been described that extracellular purines can affect some important reproductive-related functions in Sertoli
cells and germinative cells, by activating specific purinergic receptors. In this work, we report that both FSH and retinol
are able to induce changes in the levels of extracellular purines of cultured rat Sertoli cells. FSH induced an increase in
adenosine, mainly caused by enhanced ecto-ATPase activity, while retinol increased xanthine and hypoxanthine levels, and decreased
uric acid concentration by an unknown mechanism. These data indicate that purinergic signaling may be involved in the control
and/or regulation of some of the reproductive-related actions of these hormones. (Mol Cell Biochem 278: 185–194, 2005) |
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Keywords: | Sertoli FSH retinol extracellular purines purinoceptors |
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