Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives |
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| Authors: | Bharti Neelam Husain Kakul Gonzalez Garza M T Cruz-Vega Delia E Castro-Garza J Mata-Cardenas Benito D Naqvi Fehmida Azam Amir |
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| Affiliation: | Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India. |
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| Abstract: | Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug. |
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