Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets |
| |
| Authors: | Campodónico Paola R Contreras Renato |
| |
| Institution: | Instituto de Ciencias, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, código postal 771-0162, Santiago, Chile. pcampodonico@udd.cl |
| |
| Abstract: | The global electrophilicity index that incorporates electrostatic and polarizability contributions shows a quantitative correlation with antiviral and cytotoxic activities of electrophilic sugars. The model is applied to a series of compounds that behave as Michael acceptors in interaction with biological nucleophilic targets. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
