A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers

Authors:	Fan-Ching Shen Ih-Jen Su Han-Chieh Wu Yi-Hsuan Hsieh Wei-Jen Yao Kung-Chia Young Tsung-Chuan Chang Hui-Chuan Hsieh Han-Ni Tsai Wenya Huang

Institution:	(1) Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan, Republic of China;(2) Institute of Basic Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China;(3) Center for Signal Transduction and Gene Regulation, National Cheng Kung University, Tainan, Taiwan, Republic of China;(4) Division of Infectious Diseases, National Health Research Institutes, Tainan, Taiwan, Republic of China;(5) Laboratory of Molecular Diagnostics, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China;(6) Department of Radiology, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China

Abstract:	Background Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S₁ and -S₂ mutant large HBV surface antigen (LHBS), in which the pre-S₁ and -S₂ regions of the LHBS gene are partially deleted, are highly associated with HBV-related HCC.

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