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CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity |
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| Authors: | Takahashi Michiko Takahashi Yutaka Takahashi Kenichi Zolotaryov Fyodor N Hong Kyoung Su Iida Keiji Okimura Yasuhiko Kaji Hidesuke Chihara Kazuo |
| Institution: | a Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-o-ku, Kobe 650-0017, Japan b Research Affairs Center, Research Division, JCR Pharmaceuticals Co., Ltd., 2-2-10 Murotani, Nishi-ku, Kobe 651-2241, Japan c Department of Basic Allied Medicine, Kobe University School of Medicine, 7-10-2, Tomogaoka, Suma-ku, Kobe 654-0142, Japan d Division of Physiology/Metabolism, University of Hyogo, 13-71, Kita-Oji-cho, Akashi 673-8588, Japan |
| Abstract: | Accumulating evidence suggests an association between obesity and adipose tissue inflammation. Chemokines are involved in the regulation of inflammation status. Chemokine (C-X-C motif) ligand 14 (CXCL14) is known to be a chemoattractant for monocyte and dendritic cells. Recently, it was reported that CXCL14-deficient mice show resistance to high-fat diet-induced obesity. In this study, we identified CXCL14 as a growth hormone (GH)-induced gene in HepG2 hepatoma cells. Substantial in vivo expression of CXCL14 was detected in the adipose tissue and liver. Its expression and secretion were strikingly increased by insulin administration and high-fat diet. Intriguingly, incubation of 3T3-L1 adipocytes with CXCL14 stimulated insulin-dependent glucose uptake. Further, this effect was associated with enhanced insulin signaling. CXCL14 enhanced the insulin-induced tyrosine phosphorylation of insulin receptors and insulin receptor substrate-1. These results suggest that CXCL14 plays a causal role in high-fat diet-induced obesity. |
| Keywords: | CXCL14 BRAK Obesity Insulin Sensitivity Inflammation High-fat diet 3T3-L1 Adipocyte Chemokine |
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