| 谷氨酰胺代谢与肿瘤 |
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| 引用本文： | 张文静,卿国良. 谷氨酰胺代谢与肿瘤[J]. 生命科学, 2013, 0(11): 1109-1114 |
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| 作者姓名： | 张文静 卿国良 |
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| 作者单位： | [1]湖北文理学院医学院,襄阳441053 [2]华中科技大学同济医学院,武汉430030 |
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| 摘 要： | “谷氨酰胺代谢”是肿瘤细胞除Warburg效应外又一重要的能量代谢方式。迅速增殖的肿瘤细胞消耗谷氨酰胺（glutamine，Gin）来提供生长和增殖所需的能量和生物大分子原料，维持细胞内氧化还原稳态和参与细胞内信号通路的转导。肿瘤中原癌基因与抑癌基因的突变会影响Gin代谢。结合先进的诊断技术和研究手段将有利于了解肿瘤中Gln的生化代谢，揭示Gin代谢的关键环节，为依赖Gin的肿瘤提供治疗新策略。
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| 关 键 词： | 谷氨酰胺 代谢 肿瘤 代谢显像 |
Glutamine metabolism and cancer |
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| ZHANG Wen-Jing,QING Guo-Liang. Glutamine metabolism and cancer[J]. Chinese Bulletin of Life Sciences, 2013, 0(11): 1109-1114 |
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| Authors: | ZHANG Wen-Jing QING Guo-Liang |
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| Affiliation: | 1 Medical College, Hubei University of Arts and Science, Xiangyang 441053, China; 2 Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) |
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| Abstract: | Glutamine metabolism is recognized as a distinctive feature in addition to Warburg effect in cancer. Cancer cells acquire energy and nutrients through glutamine metabolism to support cell growth and proliferation. Moreover, glutamine metabolism maintains redox homeostasis and modulates cellular signal transduction. Several oncogenes and anti-oncogenes in cancers have been reported to influence glutamine metabolism. Modem diagnostic techniques combined with new methods will facilitate understanding of the biochemical processes of glutamine metabolism, unveiling the novel target and providing new therapeutics for glutamine-addicted cancers. |
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| Keywords: | glutamine metabolism cancer metabolic imaging |
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