Biomechanics of abdominal aortic aneurysm |
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Authors: | Vorp David A |
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Institution: | Department of Surgery, Division of Vascular Surgery, Department of Bioengineering, McGowan Institute for Regenerative Medicine, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, USA. VorpDA@upmc.edu |
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Abstract: | Abdominal aortic aneurysm (AAA) is a condition whereby the terminal aorta permanently dilates to dangerous proportions, risking rupture. The biomechanics of AAA has been studied with great interest since aneurysm rupture is a mechanical failure of the degenerated aortic wall and is a significant cause of death in developed countries. In this review article, the importance of considering the biomechanics of AAA is discussed, and then the history and the state-of-the-art of this field is reviewed--including investigations into the biomechanical behavior of AAA tissues, modeling AAA wall stress and factors which influence it, and the potential clinical utility of these estimates in predicting AAA rupture. |
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