Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway |
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Authors: | Tateishi Koichiro Matsushita Misao |
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Affiliation: | Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan. |
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Abstract: | MBL is a serum lectin that activates the lectin pathway of the complement system. MBL forms complexes with three types of MASPs. Upon binding to Salmonella serogroup C-specific oligosaccharide, MBL activates the alternative pathway via a C2-bypass pathway without involving MASP-2, C2 or C4. We demonstrate that mannan-bound MBL activates the alternative pathway via a C2-bypass pathway that requires MASP-2 and C4. Thus, depending on the ligands to which MBL binds, there may be two distinct MBL-mediated C2-bypass pathways. |
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Keywords: | alternative pathway complement mannose‐binding lectin |
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