Acquisition of a brief behavioral experience in the presence of neuron-specific and D2-CAM/N-CAM-specific antisera |
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Authors: | Patrick M. Nolan Robert Bell Ciaran M. Regan |
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Affiliation: | (1) Department of Pharmacology, University College, Belfield, Dublin 4, Ireland;(2) Department of Psychology, The Queen's University of Belfast, BT7 INN Belfast, Northern Ireland |
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Abstract: | The effect of intraventricular infusion of D2-CAM/N-CAM directed antibodies prior to the acquisition of a passive-avoidance paradigm is described. The antisera used in this study were the neuron specific anti-BPM and a D2-CAM/N-CAM specific serum, anti-D2. Anti-BPM reliably inhibited paradigm acquisition when recall was ascertained at 24 and 48 hours and no effect was noted with absorbed anti-BPM or in sham-operated animals. This effect was time-dependent and no inhibition of memory formation was noted when the antiserum was administered at 6 and 10 hours after training. In contrast, infusion of anti-D2 had no effect on paradigm acquisition. These findings are discussed in relation to the potential synaptogenic events associated with memory formation. |
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Keywords: | D2-CAM/N-CAM memory/learning passive-avoidance synapse formation |
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