Evaluation of Biotin-OSu and Biotin-ONp in the Solid Phase Biotinylation of Peptides期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Evaluation of Biotin-OSu and Biotin-ONp in the Solid Phase Biotinylation of Peptides

Authors:	Bodo?Baumeister author-information" > author-information__contact u-icon-before" > mailto:bodo.baumeister@merckbiosciences.ch" title=" bodo.baumeister@merckbiosciences.ch" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,J.?Beythien,J.?Ryf,P.?Schneeberger,Peter?D.?White

Affiliation:	(1) Novabiochem, Merck Biosciences AG, CH-4448, Läufelfingen, Switzerland;(2) Novabiochem, Merck Biosciences Ltd, Padge Road, NG9 2JR Beeston, England;(3) Correspondence Should be addressed to: Bodo Baumeister, Novabiochem, Merck Biosciences Ltd, Padge Road, NG9 2JR Beeston, England

Abstract:	Biotinyl-oxysuccinimide and biotin p-nitrophenyl ester were evaluated in the solid phase synthesis of biotinylated peptides. Biotin p-nitrophenyl ester was found to be superior in terms of solubility and reactivity.

Keywords:	Biotin Biotin N-hydroxysuccinimide ester Biotin p-nitrophenyl ester Biotinylation Fmoc solid phase peptide synthesis N-(biotinyloxy)succinimide
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